VIP

Vasoactive Intestinal Peptide (VIP) is a unique peptide often used in research for its potent anti-inflammatory effects, particularly in the context of Chronic Inflammatory Response Syndrome (CIRS), mold illness, and lung health.

Because VIP affects blood pressure and heart rate, the protocol is typically more cautious than other peptides. Here is the standard research breakdown for a subcutaneous injection protocol.
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1. Reconstitution & Dosage
VIP is usually sold in 2mg or 5mg vials. For this example, let's assume a 2mg vial as it's the most common for starting protocols.

• Reconstitution: Add 2ml of Bacteriostatic Water to a 2mg vial.
• The Concentration: This creates a concentration of 1,000mcg (1mg) per 1ml.
• The Dose: On a standard U-100 insulin syringe:
o 5 units (0.05ml) = 50mcg (Common starting dose)
o 10 units (0.10ml) = 100mcg
o 20 units (0.20ml) = 200mcg

Typical Dosage Ranges:
• Starting Dose: 50mcg once daily.
• Standard Research Dose: 100mcg – 200mcg once daily.
• Note: Researchers often start low to monitor for "flushing" or heart rate changes.
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2. The Cycle (Duration & Timing)
VIP is often used for longer durations to downregulate chronic inflammation, but it should still be cycled.

Goal Typical Cycle Frequency
Inflammation/CIRS 4–8 Weeks ON / 4 Weeks OFF Once daily (Morning)
Acute Lung/Immune Support 2 Weeks ON / 2 Weeks OFF Once daily

Pro Tip: Most researchers prefer morning administration. VIP can occasionally be slightly stimulatory or cause a temporary "flush" that might be uncomfortable right before bed.
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3. Important Administration Rules

• Sit Down: For the first few doses, it is highly recommended to be sitting down. VIP is a vasodilator (it widens blood vessels), which can cause a temporary drop in blood pressure or a rapid heartbeat (tachycardia) immediately after injection.

• The "Flush": Do not be alarmed if you feel a warm sensation in your face or chest shortly after the injection. This is a known effect of VIP and usually subsides within 10–15 minutes.
• Empty Stomach: Like most peptides, it is best absorbed when taken at least 1 hour away from food.
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4. Storage & Stability

• Very Fragile: VIP is one of the most delicate peptides. It must be refrigerated at all times after reconstitution.

• No Shaking: Even more than Tesa or Selank, VIP is sensitive to kinetic energy. Do not shake the vial; let the water dissolve the powder naturally.
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5. Potential Side Effects
• Facial Flushing: Redness or warmth in the face.
• Tachycardia: A brief increase in heart rate.
• Loose Stools: At higher doses, VIP can stimulate the digestive tract.
• Dizziness: Due to the vasodilatory effect (dropping blood pressure).
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Safety Warning: VIP should be used with extreme caution by anyone with a history of low blood pressure or certain heart conditions. It is also generally avoided if there is a suspicion of VIPoma (a specific type of tumor). Always consult a physician, especially when dealing with CIRS or inflammatory conditions.