

Thymosin Alpha-1
What is Thymosin Alpha-1?

Thymosin alpha-1 (Tα1) is a natural peptide hormone from the thymus gland that regulates and enhances the immune system, boosting T-cell function, fighting infections (viral, bacterial), and potentially helping with cancers or autoimmune issues by improving the body's immune response, acting as an "immune boss" that tells immune cells how to fight. Approved in many countries (like Zadaxin) for infections/cancer but often used off-label in the U.S., it's given via injection to support immune deficiency and other conditions.
Key Functions & Uses
--Immune Regulation: Enhances T-cell maturation and activity, crucial for fighting pathogens.
--Infections: Shown to help with viral (Hepatitis B/C, COVID-19, Lyme) and bacterial infections.
--Cancer: Used in combination with chemotherapy to boost anti-tumor response.
--Autoimmune & Inflammatory: Investigated for autoimmune diseases, inflammation, and conditions like ME/CFS.
--Vaccine Response: Can improve immune response to vaccines.
How It Works
It's a 28-amino acid peptide, part of Thymosin Fraction 5, that activates immune cells like dendritic cells, prompting them to produce cytokines and fight illness.
It modulates both innate and adaptive immunity, helping the body respond to sickness and control excessive inflammation.
Availability & Administration
--Synthetic Version: Thymalfasin (ZADAXIN) is the synthetic, identical form of natural Tα1 used clinically.
--Administration: Typically given as subcutaneous injections (twice weekly is common).
--Status: Approved in over 35 countries, but in the U.S., it's often prescribed off-label by compounding pharmacies.