Tesamorelin

Tesamorelin (brand names Egrifta SV and Egrifta WR) is a prescription synthetic peptide medication used to reduce excess visceral abdominal fat in adults with HIV who have lipodystrophy. It is not a general weight-loss drug for obesity.

Tesamorelin is a potent Growth Hormone Releasing Hormone (GHRH) analog. Unlike the "calm" or "focus" peptides like Selank and Semax, Tesamorelin is primarily used for physical optimization—specifically reducing visceral adipose tissue (belly fat) and increasing IGF-1 levels.

Since you have 10mg vials, the protocol is quite different from the previous peptides because the standard clinical dose is relatively high.
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1. Reconstitution & Dosage
Tesamorelin is notorious for being "fragile" and requiring a higher volume of diluent.

• Standard Reconstitution: Add 2ml of Bacteriostatic Water to the 10mg vial.
• The Concentration: This creates a concentration of 5mg per 1ml.
• The Dose: The FDA-approved clinical dose (for Egrifta) is 2mg per day.
o On a standard U-100 insulin syringe, 2mg would be 40 units (0.4ml).

Common Research Dosages:
• Standard Protocol: 2mg per day (40 units).
• Conservative Protocol: 1mg per day (20 units).
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2. The Cycle (Duration & Timing)
Tesamorelin works best when it mimics the body's natural growth hormone pulses.

Parameter Recommendation
Cycle Length 8–12 Weeks ON / 4 Weeks OFF
Weekly Schedule 5 Days ON / 2 Days OFF (to prevent pituitary exhaustion)
Timing Nightly, ideally 2–3 hours after your last meal.

Important Rule: You must administer Tesamorelin on an empty stomach. High blood sugar or insulin levels can blunt the growth hormone pulse, making the peptide much less effective. Most users take it right before bed.
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3. Expected Results & Timeline
• Weeks 1-4: Improved sleep quality and faster recovery from workouts.
• Weeks 4-8: Increased lean muscle tone and the beginning of visceral fat loss.
• Weeks 8-12: Noticeable changes in body composition (specifically the midsection).
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4. Storage & Handling
• Extreme Sensitivity: Tesamorelin is more sensitive to heat and light than Selank or Semax.
• Refrigeration: Must be refrigerated immediately after reconstitution.
• Handling: Do not "squirt" the water directly onto the powder; let it dribble down the side of the glass. Do not shake.
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5. Potential Side Effects
Because Tesamorelin significantly boosts Growth Hormone, you may experience:
• Water Retention: Slight swelling in the hands or ankles.
• Joint Discomfort: Mild aching in the wrists or fingers (Carpal Tunnel-like symptoms).
• Injection Site Reaction: Redness or itching (Tesamorelin is known for being a bit "spicy" upon injection).
• Blood Sugar: It can occasionally affect insulin sensitivity, so monitoring fasted blood glucose is a good idea.
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Safety Note: Tesamorelin should be avoided by anyone with active malignancy or cancer, as growth hormone can potentially accelerate the growth of existing tumors. Always consult with a healthcare professional before beginning GHRH therapy.


It is a prescription-only medication and should only be used under strict medical supervision. The fat reduction effects are temporary and typically reverse if the treatment is discontinued.