SLU-PP-332

SLU-PP-332 is an experimental, synthetic small molecule (often referred to as a peptide in popular literature) that acts as an "exercise mimetic". It is designed to replicate some of the metabolic benefits of physical exercise by activating specific proteins in the body.

Mechanism of Action

SLU-PP-332 functions as an agonist for all three forms of estrogen-related receptors (ERRα, ERRβ, and ERRγ), with the strongest effect on ERRα. These nuclear receptors are master regulators of energy production and are highly expressed in energy-intensive tissues like muscle, the heart, and the brain.

By activating the ERR pathways, the compound increases the expression of genes related to energy expenditure and mitochondrial biogenesis (the creation of new mitochondria, the cell's powerhouses). This prompts the body's muscles to use more fatty acids for fuel, essentially "tricking" the body into a state similar to one that has undergone endurance training.

Research Findings and Potential Applications
Current research on SLU-PP-332 has been conducted in cellular and animal (mouse) models, showing promising results for treating various conditions.

--Weight Loss & Metabolic Health: In obese mice, administration of SLU-PP-332 led to significant fat mass loss (up to 12% of body weight) without changes in diet or activity, while also improving insulin sensitivity and glucose regulation.
--Enhanced Endurance: Treated mice showed increased physical stamina and could run nearly 50% farther on a treadmill.
--Disease Treatment: It is being investigated for potential use in treating metabolic syndrome, type 2 diabetes, non-alcoholic fatty liver disease, heart failure, and age-related muscle loss.
Important Considerations
--Research Only: SLU-PP-332 is currently for scientific research use only and is not approved by the FDA or any other regulatory body for human use or consumption.
--No Human Trials: As of late 2025, no clinical trials have been conducted on humans. Its long-term safety, side effects, and effective dosage in people are unknown.

Not a Replacement for Exercise: Experts emphasize that while it mimics some metabolic effects, it does not replicate the full range of neurological, hormonal, and physical benefits of actual exercise.

It is essential to consult with a licensed medical professional before considering any new compound, especially those that are still in early research stages.