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Sermorelin

What is Sermorelin?

Sermorelin is often considered the "grandfather" of Growth Hormone Releasing Hormones (GHRH). It was the first of its kind to be FDA-approved. It works similarly to Tesamorelin but has a shorter half-life and is generally used more for overall "anti-aging," improved sleep, and recovery rather than aggressive visceral fat loss.

Since you are likely looking at a 5mg or 10mg vial, here is the protocol for research.
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1. Reconstitution & Dosage

Sermorelin is typically dosed in micrograms (mcg).
• Reconstitution: Add 3ml of Bacteriostatic Water to a 5mg vial (or 6ml to a 10mg vial).
• The Concentration: This creates a concentration of roughly 1,666mcg per 1ml.
• The Dose: On a standard U-100 insulin syringe:
o 12 units (0.12ml) ≈ 200mcg (Common starting dose)
o 18 units (0.18ml) ≈ 300mcg (Standard "anti-aging" dose)
o 30 units (0.30ml) ≈ 500mcg (Performance/Recovery dose)

Common Dosage Ranges:
• Standard: 200mcg – 300mcg per day.
• Aggressive: Up to 500mcg per day.
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2. The Cycle (Duration & Timing)
Sermorelin is very effective for long-term use, but it still benefits from a "pulse" schedule to keep the pituitary gland responsive.

Parameter Recommendation
Cycle Length 3–6 Months (It takes time to see the "glow" effects)
Weekly Schedule 5 Days ON / 2 Days OFF

Timing Nightly, 30 minutes before bed and at least 2 hours after your last meal.

The "Sermorelin Secret": Unlike some other GH peptides, Sermorelin is famous for its "sleep-inducing" side effect. Taking it right before bed can significantly increase deep sleep (REM) quality.
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3. Expected Benefits (The Timeline)
• Month 1: Deep, restful sleep and improved vivid dreaming.
• Month 2: Improved skin elasticity and faster recovery from exercise.
• Month 3: Improved muscle tone and decreased body fat.
• Month 6: The "fountain of youth" effects—improved hair/nail quality and overall vitality.
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4. Storage & Stability
• Refrigeration: Must be kept in the fridge after mixing.
• Longevity: Sermorelin is relatively stable but will start to degrade after 25–30 days in the fridge. If you have a 10mg vial but only use 200mcg a day, it might lose potency before you finish it; 5mg vials are often better for individual use.
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5. Potential Side Effects
• The "Glow" Flush: You may feel a slight warmth or flushing in your face for 10 minutes after injection.
• Tingling Hands: High doses can cause slight "pins and needles" in the fingers (water retention).
• Vivid Dreams: For most, this is a benefit, but it can be intense for some.
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Comparison: Sermorelin vs. Tesamorelin

Quick difference:
• Tesamorelin: More "heavy-duty" for fat loss; higher doses; more expensive.
• Sermorelin: Better for sleep, skin, and long-term wellness; more affordable; gentler on the system.

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