Sermorelin

Sermorelin is a synthetic peptide that mimics the body's natural growth hormone-releasing hormone (GHRH). It stimulates the pituitary gland to produce and release more of its own natural human growth hormone (hGH) in a pulsatile, regulated manner.

Key Information
--Mechanism: Sermorelin acts as a "secretagogue," meaning it encourages your body to make its own hGH, rather than introducing synthetic hGH directly. This approach is often considered to have a better safety profile than direct hGH injections, as the body's natural feedback loops (like somatostatin) prevent excessive hGH levels.
--FDA Status: Sermorelin was originally FDA-approved in the 1990s to treat growth hormone deficiency (GHD) in children. The manufacturer discontinued the brand-name product (Geref) in 2008 for business reasons, not safety concerns. It is currently available through compounding pharmacies as a custom-made medication, which means it is used off-label in adults and not individually FDA-approved.
--Prescription: It is a prescription-only medication and is not a controlled substance.
Athletic Use: Sermorelin is a prohibited substance at all times by the World Anti-Doping Agency (WADA) and the U.S. Anti-Doping Agency (USADA) due to its performance-enhancing potential.

Common Uses and Potential Benefits
--Sermorelin is primarily used off-label in adults to address age-related decline in hGH and the associated symptoms. Reported benefits may include:
--Improved body composition: Increased lean muscle mass and reduced body fat.
--Increased energy and vitality: Reduced fatigue and improved stamina.
--Enhanced recovery: Faster healing from workouts and injuries.
--Better sleep quality: Deeper, more restorative sleep patterns.
--Improved skin health: Increased skin elasticity and reduced wrinkles due to collagen synthesis.
--Increased bone density: Support for stronger bones and reduced risk of osteoporosis.

Administration and Side Effects
Sermorelin is typically administered via subcutaneous injection (under the skin), often at night to coincide with the body's natural hGH release. It can take several weeks to months to notice the full effects.

Common side effects are usually mild and temporary, and may include:
--Redness, pain, or swelling at the injection site
--Headaches
--Dizziness or flushing
--Nausea

Serious side effects are rare when the treatment is supervised by a medical professional.