Semax

Semax is a synthetic peptide medication developed in Russia, where it is approved for medical use as a nootropic and neuroprotective agent. It is not approved by the FDA in the United States and is generally sold as a research chemical or prescribed off-label by some wellness clinics.

Key Information
--Mechanism of Action: Semax is an analogue of a fragment of adrenocorticotropic hormone (ACTH), specifically ACTH (4-10), but is devoid of hormonal activity. It works by rapidly increasing levels of brain-derived neurotrophic factor (BDNF), a protein crucial for neuron growth and survival, and by modulating neurotransmitters like dopamine and serotonin.
--Administration: It is most commonly administered as a nasal spray, which allows it to effectively cross the blood-brain barrier. It can also be administered via subcutaneous injection.

Approved Uses (in Russia and Eastern Europe):
--Treatment of ischemic stroke and transient ischemic attacks.
--Management of cognitive disorders, memory impairment, and attention deficits.
--Treatment of optic nerve diseases.
--Boosting the immune system.
--Other Potential/Experimental Uses: Outside of its approved clinical uses, Semax is used by some in the nootropic community for:
--Cognitive enhancement (improved memory, focus, and learning capacity).
--Mood regulation, including relief from anxiety and depression symptoms.
--Managing symptoms of ADHD.
--Recovery from traumatic brain injury and chronic stress.

Side Effects: Semax is generally considered well-tolerated with mild potential side effects, which can include nasal irritation, headaches, increased blood pressure, or temporary mood changes/irritability.

Legal Status (US): Semax is not evaluated or approved by the FDA for any medical use in the United States. It is often sold online as a "research chemical," but legitimate medical use requires a prescription and physician supervision in the US from clinics that offer peptide therapy.