Semax

Semax is a heptapeptide analog of ACTH (adrenocorticotropic hormone) that was originally developed in Russia. It is categorized as a nootropic and neuroprotective agent. In research, it is primarily studied for its ability to increase Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF), which are essential for neuron survival and synaptic plasticity.

While Semax is famously used as a nasal spray, the subcutaneous (SubQ) injection method is often preferred in research for its 100% bioavailability and more consistent systemic effects.
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1. Reconstitution & Dosage
Semax typically comes in 10mg, 20mg, or 30mg lyophilized vials. Because the dosage is measured in micrograms, precise measurement is key to managing its stimulatory effects.

• Reconstitution: Add 2ml of Bacteriostatic Water to a 10mg vial.
• The Concentration: This creates 5mg (5,000mcg) per 1ml.
• Syringe Measurement (U-100 Insulin Syringe):
o 5 units (0.05ml) = 250mcg (Starting/Micro-dose)
o 10 units (0.10ml) = 500mcg (Standard Research dose)
o 20 units (0.20ml) = 1,000mcg (High-end Acute dose)
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2. The Cognitive Protocol
Unlike metabolic peptides, Semax works best when used to "prime" the brain for high-output cognitive tasks.

Parameter Recommendation
Weekly Schedule 5 Days ON / 2 Days OFF (To prevent receptor downregulation)
Cycle Length 4–6 Weeks ON / 2–4 Weeks OFF
Timing Morning Only. Due to its stimulatory nature, taking it after 2:00 PM may interfere with sleep.

The "Stacking" Logic: Researchers often stack Semax with Selank (an anxiolytic peptide). Semax provides the focus/drive, while Selank provides the calm/clarity, creating a "flow state" environment.
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3. Administration & Storage

• Injection Type: Subcutaneous (SubQ). Standard fatty tissue injection sites (stomach or thigh).

• Storage: Semax is highly sensitive to heat. It must be refrigerated immediately after reconstitution.

• Sensitivity: It is more stable than VIP but should still be handled gently. Avoid shaking the vial to prevent the degradation of the peptide bonds.
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4. Expected Effects & Side Effects
• The "Lifting of the Fog": Researchers report an immediate improvement in mental clarity, verbal fluency, and the ability to process complex information.
• Neuroprotection: Used in studies involving recovery from stroke or traumatic brain injury (TBI).
• Side Effects: * Insomnia/Anxiety: Usually only if the dose is too high or taken too late in the day.
o Irritability: Occasionally reported as a "come down" effect after the peak concentration passes.
o Hair Thinning: A rare but notable anecdotal side effect. High levels of BDNF can theoretically shift hair follicles into the resting phase in some individuals.
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Quick Checklist for a 10mg Vial:
• At 500mcg/day: One vial lasts 20 days (perfect for a standard 1-month cycle with "off" days).
• Supplies: 31g, 5/16" (8mm) insulin syringes.
• Visuals: The reconstituted liquid should be perfectly clear. If it is cloudy, the peptide has been damaged or contaminated.