Selank

Selank is a synthetic analog of the naturally occurring peptide Tuftsin, but with an added proline-rich sequence to improve its stability and penetration into the brain. It is primarily researched as an anxiolytic (anti-anxiety) and nootropic agent.

Unlike traditional anti-anxiety medications, Selank does not cause sedation or physical dependence. Instead, it modulates GABA receptors and influences the expression of Brain-Derived Neurotrophic Factor (BDNF) to provide a "calm but focused" state.

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1. Reconstitution & Dosage
Selank usually comes in 5mg or 10mg lyophilized vials. Because it is highly potent, precise reconstitution is necessary for accurate micro-dosing.

• Reconstitution: Add 2ml of Bacteriostatic Water to a 10mg vial.
• The Concentration: This creates 5mg (5,000mcg) per 1ml.
• Syringe Measurement (U-100 Insulin Syringe):
o 5 units (0.05ml) = 250mcg (Starting/Threshold Dose)
o 10 units (0.10ml) = 500mcg (Standard Research Dose)
o 20 units (0.20ml) = 1,000mcg (1mg - High-end therapeutic dose)
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2. The "Calm & Clarity" Protocol
Selank is highly versatile. In research, it is either used "as needed" for acute stress or as a daily cycle for general cognitive stabilization.

Parameter Recommendation
Weekly Schedule 5 Days ON / 2 Days OFF
Cycle Length 4–8 Weeks
Frequency 1 to 2 times daily
Timing Morning (for daytime clarity) or Late Afternoon (to wind down).

The "Focus Stack": Selank is frequently paired with Semax. While Semax provides the "gas" (mental energy/drive), Selank provides the "steering" (emotional stability/anxiety reduction).
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3. Administration & Storage

• Injection Type: Subcutaneous (SubQ). Typical sites include the abdomen or thigh fat.

• Storage: Selank is sensitive to heat and degradation. It must be refrigerated after reconstitution.

• Stability: Avoid exposing the vial to direct sunlight. Once mixed, it is generally stable for 30 days in the refrigerator.
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4. Expected Effects & Safety
• Anxiolytic Effect: Researchers often note a reduction in the "noise" of internal anxiety without the "brain fog" associated with benzodiazepines.
• Enhanced Learning: By increasing BDNF, it may help in the formation of new memories and synaptic connections.
• Side Effects: Selank is remarkably well-tolerated. Rare side effects include:
o Slight fatigue (if the dose is excessively high).
o Mild headache during the first few days of use.
o Increased vividness of dreams.
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Quick Checklist for a 10mg Vial:
• At 500mcg/day: One vial lasts 20 days.
• At 250mcg 2x/day: One vial lasts 20 days.
• Supplies: 31g Insulin syringes.