Pinealon

Pinealon is a synthetic tripeptide (composed of three amino acids: Glu-Asp-Arg) that is part of the "bioregulator" family of peptides. It is primarily used in research to support brain health, cognitive function, and the health of the pineal gland.

Unlike the growth hormone peptides or metabolic exercise mimetics, Pinealon is often used in short, intensive bursts to help "reset" biological rhythms and neuronal health.
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1. Reconstitution & Dosage
Pinealon usually comes in 10mg or 20mg vials. Because it is a small peptide chain, it is relatively stable and dissolves easily.

• Reconstitution: Add 2ml of Bacteriostatic Water to a 10mg vial.
• The Concentration: This creates 5mg per 1ml.
• Syringe Measurement: On a standard U-100 insulin syringe:
o 10 units (0.1ml) = 500mcg
o 20 units (0.2ml) = 1mg

Common Research Dosages:
• Maintenance/Nootropic Support: 500mcg to 1mg per day.
• Intensive Support (Post-injury or Sleep Reset): 2mg to 5mg per day for a short duration.
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2. The Cycle (Duration & Frequency)
Bioregulators like Pinealon are meant to be "pulsed." You aren't replacing a hormone; you are sending a signal to the cells to repair themselves.

Goal Typical Cycle Frequency
Cognitive Boost 10–20 Days ON Once Daily
Biannual "Reset" 10 Days ON Once Daily (Done twice a year)
Chronic Support 20 Days ON / 4–6 Months OFF Once Daily

Pro Tip: For the best results, many researchers run Pinealon for 10 to 20 consecutive days and then take a long break (several months) before doing it again.
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3. Timing & Benefits
• Timing: Best administered in the morning. Since it influences the pineal gland and circadian rhythms, morning use helps signal the "wake" phase of your biological clock.
• Expected Effects: Most users don't "feel" a rush. Instead, they report improved sleep quality over time, better concentration, and enhanced memory retention. It is often described as a "de-fogging" of the brain.
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4. Storage & Stability
• Refrigeration: Like your other peptides, keep it in the fridge after mixing.
• Stability: Pinealon is fairly hardy, but it’s best used within 30 days of reconstitution.
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5. Potential Side Effects
Pinealon is remarkably well-tolerated with almost no reported side effects in clinical literature.
• Vivid Dreams: Because of its effect on the pineal gland/melatonin pathways, you may experience more intense dreaming.
• No Crash: Unlike caffeine or traditional nootropics, it doesn't have a "come down" or crash associated with use.
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The "Nootropic Stack" Idea
Researchers often stack Pinealon with Semax for a comprehensive brain-health protocol:
• Pinealon: Handles the "deep repair" and circadian rhythm.
• Semax: Provides the "active" focus and BDNF (brain-derived neurotrophic factor) boost.