Pinealon

Pinealon (also known as EDR or Glu-Asp-Arg) is a synthetic, three-amino-acid peptide that functions as a bioregulator in the central nervous system. It is primarily researched for its potential neuroprotective, cognitive-enhancing, and anti-aging properties.

Key Characteristics and Function
--Structure: Pinealon is a tripeptide composed of L-glutamic acid, L-aspartic acid, and L-arginine.
--Mechanism of Action: Unlike most peptides that bind to cell surface receptors, Pinealon's small size allows it to potentially cross cell and nuclear membranes to interact directly with DNA. This is believed to modulate gene expression related to cellular metabolism, resistance to oxidative stress, and brain plasticity.
--Origin: It was originally derived from natural polypeptide extracts of brain tissue (known as Cortexin) and developed by Russian scientists for use in extreme stress environments.

Potential Benefits and Research Applications
Research, largely in animal models and small-scale human studies, has explored several potential applications for Pinealon:
--Neuroprotection: It helps protect neurons from damage caused by lack of oxygen (hypoxia) and oxidative stress by suppressing free radical accumulation and reducing programmed cell death (apoptosis).
--Cognitive Enhancement: Studies suggest Pinealon may improve memory, learning ability, focus, and mental clarity, particularly in cases of age-related decline or brain injury.
--Circadian Rhythm Regulation: By affecting the pineal gland, it may help regulate sleep-wake cycles and improve sleep quality, which can be beneficial for shift workers or those with sleep disturbances.
--Anti-Aging (Geroprotective) Effects: It has been linked to mechanisms that slow cellular aging, such as promoting telomere stability and mimicking some effects of physical exercise by influencing the hormone irisin.

Status and Availability
Pinealon is considered an experimental or research-use-only compound in many countries, including the United States, and is not approved by the FDA as a medicine or drug for human consumption. It is sometimes available through specialized clinics or research suppliers, often administered via subcutaneous injection or sublingual spray, but always requires medical supervision and informed consent due to limited large-scale clinical trial data.