PE-22-28

PE-22-28 is a novel neuropeptide derived from Spadin. In research, it is studied as a rapid-acting antidepressant that works by blocking TREK-1 potassium channels. Unlike traditional SSRIs, which can take weeks to show effects, PE-22-28 is researched for its ability to produce significant cognitive and mood-enhancing results within as little as 4 to 7 days.

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1. Reconstitution & Dosage
PE-22-28 is typically found in 5mg or 10mg vials. Because it is highly bioavailable, doses remain relatively low.

• Reconstitution: Add 2ml of Bacteriostatic Water to a 10mg vial.
• The Concentration: This creates 5mg (5,000mcg) per 1ml.
• Syringe Measurement (U-100 Insulin Syringe):
o 8 units (0.08ml) = 400mcg (Standard research dose)
o 12 units (0.12ml) = 600mcg (High-intensity dose)

Common Research Dosages:
• Standard Dose: 400mcg once daily.
• Frequency: 7 days a week for the duration of the cycle.
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2. The Cycle (Duration & Timing)
PE-22-28 is generally used in short-to-medium cycles to "reset" the mood or combat periods of high stress/burnout.

Phase Duration Frequency
Active Cycle 4 to 6 Weeks Once Daily
The Break 4 Weeks OFF

Timing: It is best administered in the morning. Many researchers report a slight increase in mental energy and motivation, which is ideal for the start of the day.
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3. Administration
• Subcutaneous (SubQ): Standard abdominal fat injection.
• Intranasal: PE-22-28 is also frequently researched via intranasal spray to bypass the blood-brain barrier more efficiently, though SubQ remains the most reliable for consistent dosing.
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4. Storage & Stability
• Refrigeration: Mandatory after reconstitution.
• Stability: Like most neuropeptides, it is sensitive. Keep it away from direct light and avoid shaking the vial.
• Shelf Life: Potency remains high for 21–28 days in the fridge.
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5. Potential Side Effects
• Headache: Mild, transient headaches are occasionally reported during the first 3 days as the brain adjusts.
• Vivid Dreams: Some researchers notice an increase in dream intensity.
• No "Crash": Unlike stimulant-based mood boosters, PE-22-28 does not typically cause a crash or withdrawal upon cessation.
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The "Neuro-Mood" Stack
To maximize brain health, researchers often stack PE-22-28 with Semax or ADAMAX:
1. PE-22-28: Targets the TREK-1 channel for rapid mood support.
2. ADAMAX: Boosts BDNF for focus and long-term neuroplasticity.
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Quick Checklist for a 10mg Vial:
• At 400mcg/day: One vial lasts 25 days.
• At 600mcg/day: One vial lasts ~16 days.