LL-37

LL-37 is a potent antimicrobial peptide (AMP) that is part of the body’s innate immune system. In a research context, it is studied for its ability to fight chronic infections (biofilms), support wound healing, and modulate the immune response.

Because LL-37 is an antimicrobial, the protocol is usually shorter and more aggressive than a long-term wellness peptide.
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1. Reconstitution & Dosage
LL-37 typically comes in 5mg vials.

• Reconstitution: Add 2ml of Bacteriostatic Water to a 5mg vial.
• The Concentration: This creates 2.5mg (2,500mcg) per 1ml.
• Syringe Measurement: On a standard U-100 insulin syringe:
o 4 units (0.04ml) = 100mcg
o 8 units (0.08ml) = 200mcg
o 20 units (0.20ml) = 500mcg

Common Research Dosages:
• Starting Dose: 100mcg – 200mcg per day.
• Standard Therapeutic Dose: 250mcg – 500mcg per day.
• Note: Some research protocols for severe chronic infection go higher, but starting low is critical to monitor for a "Herxheimer" reaction.
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2. The Cycle (Duration & Frequency)
LL-37 is generally used until the targeted issue (like a chronic infection or wound) has improved.

Goal Duration Frequency
Acute Infection Support 10–14 Days Once Daily
Chronic Biofilm/Gut Issues 3–4 Weeks Once Daily

Pro Tip: Do not exceed 4 weeks of continuous use. Like many antimicrobials, the body needs a break to ensure the "good" bacteria and the immune system stay balanced.
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3. The "Herx" Reaction Warning
Because LL-37 is very effective at killing pathogens (bacteria, fungi, viruses), you might experience a Herxheimer Reaction (die-off).

• Symptoms: Flu-like feelings, fatigue, joint pain, or skin breakouts.
• Management: if this happens, most researchers cut the dose in half or switch to "Every Other Day" injections until the symptoms subside.
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4. Storage & Stability
• Refrigeration: Keep it in the fridge after mixing.
• Stability: LL-37 is moderately stable, but for best results, finish the vial within 21–30 days.
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5. Potential Side Effects
• Injection Site Irritation: It can be slightly "stinging" upon injection.
• Systemic Inflammation: In rare cases, it can cause a temporary flare in inflammatory markers as the immune system is activated.
• Autoimmune Caution: Like Thymosin Alpha-1, use extreme caution if you have an active autoimmune condition, as LL-37 is a pro-inflammatory signaling molecule in certain contexts (like Psoriasis).
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The "Healing Stack"
Researchers often stack LL-37 with BPC-157:
• LL-37: Kills off the underlying infection or pathogen.
• BPC-157: Repairs the tissue damage left behind.