KPV

KPV (Lysine-Proline-Valine) is a potent naturally occurring tripeptide that acts as a powerful anti-inflammatory and antimicrobial agent. It is a C-terminal fragment of Alpha-MSH, but unlike its parent molecule, KPV does not cause skin tanning.

In research, it is most often used to target gut inflammation (IBD/IBS), skin conditions (psoriasis/eczema), and systemic mast cell activation (MCAS).
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1. Reconstitution & Dosage
KPV usually comes in 5mg or 10mg vials.

• Reconstitution: Add 2ml of Bacteriostatic Water to a 10mg vial.
• The Concentration: This creates 5mg (5,000mcg) per 1ml.
• Syringe Measurement: On a standard U-100 insulin syringe:
o 4 units (0.04ml) = 200mcg
o 10 units (0.10ml) = 500mcg
o 20 units (0.20ml) = 1mg

Common Research Dosages:
• Standard Anti-Inflammatory Dose: 200mcg – 500mcg per day.
• Intensive Gut/Systemic Repair: 1mg (1,000mcg) per day.
• Note: KPV is very potent at small doses; most researchers find 500mcg to be the "sweet spot."
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2. The Cycle (Duration & Frequency)
KPV is often used as a "fire extinguisher" for inflammation.

Goal Duration Frequency
Acute Flare-up (Gut/Skin) 10–14 Days Once Daily
Chronic Inflammation 4–6 Weeks Once Daily
Maintenance 2 Weeks ON / 2 Weeks OFF Once Daily
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3. Administration Methods
• Subcutaneous (SubQ): Most common for systemic inflammation. Use the Abdominal Quadrant Map we created earlier.
• Oral (Capsules): Often preferred specifically for Crohn's or Ulcerative Colitis, as the peptide needs to reach the intestinal tract directly.
• Topical: Sometimes mixed into creams for localized psoriasis or dermatitis.
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4. Storage & Stability
• Refrigeration: Must be kept in the fridge after reconstitution.
• Stability: KPV is a very stable tripeptide. It can typically last 30–60 days in the refrigerator without significant loss of potency.
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5. Potential Side Effects
KPV is remarkably well-tolerated because it is a naturally occurring fragment in the human body.
• Minimal Side Effects: There are virtually no reported side effects at standard dosages.
• No Tanning: Unlike Melanotan II, KPV does not bind to the MC1R receptor, so it will not change your skin pigment.
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The "Autoimmune/Gut" Stack
Researchers frequently stack KPV with BPC-157:
• KPV: Shuts down the "inflammatory fire" and overactive immune response.
• BPC-157: Focuses on the structural "brick and mortar" repair of the gut lining or tissue.
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Quick Checklist for your 10mg Vial:
• To hit a 500mcg dose: Pull to the 10 unit mark on your syringe (assuming 2ml of water). One vial will last you 20 days.

Gut Health & Anti-Inflammatory Log
Protocol: Daily Administration (Morning is best for Gut/MCAS support)

Day Date KPV Dose (500mcg) BPC-157 Dose (250mcg) Gut/Skin Symptoms (1-10)
1 10 units 10 units
2 10 units 10 units
3 10 units 10 units
4 10 units 10 units
5 10 units 10 units
6 10 units 10 units
7 10 units 10 units
8 10 units 10 units
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Preparation & Math Cheat Sheet

Vial 1: KPV (10mg)
• Reconstitute with: 2ml Bacteriostatic Water
• Concentration: 5mg/ml
• Dose (500mcg): 10 Units on an insulin syringe.

Vial 2: BPC-157 (5mg)
• Reconstitute with: 2ml Bacteriostatic Water
• Concentration: 2.5mg/ml
• Dose (250mcg): 10 Units on an insulin syringe.
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Stacking Pro-Tips:
1. Can I mix them in one syringe? In research, many combine these into a single syringe to save on "pokes." Just ensure you draw up the KPV first, then the BPC-157 (or vice versa) and inject immediately.
2. Timing: For gut issues, many researchers find taking this stack 30 minutes before breakfast on an empty stomach provides the best signal to the digestive tract.
3. The "Flare" Rule: If you are in the middle of a severe inflammatory flare, some protocols increase KPV to 1mg (20 units) for the first 3 days to bring the inflammation down quickly, then drop back to 500mcg for maintenance.
4. Storage: Both are stable in the fridge. BPC-157 is slightly more "bouncy" and durable than the ultra-fragile GH peptides, but KPV is the "tank"—it's very stable.
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Supplies Needed for a 30-Day Cycle:
• KPV: 2 x 10mg Vials
• BPC-157: 2 x 5mg Vials
• Syringes: 30 (if mixing) or 60 (if injecting separately)
• Bac Water: 1 x 30ml vial