Glutathione

Glutathione is the body’s "Master Antioxidant." While not a peptide in the functional sense (it's a tripeptide made of cysteine, glycine, and glutamic acid), it is a cornerstone of cellular detoxification.

Because oral glutathione is largely broken down by the digestive system, subcutaneous (SubQ) or Intramuscular (IM) injections are the preferred research methods for achieving high systemic levels.
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1. The Concentration (Reconstitution)
Glutathione typically comes in large vials, often 200mg/ml in pre-mixed pharmacy vials, or in 500mg or 1000mg (1g) lyophilized powder vials.

• Reconstitution (for 1000mg powder): Add 5ml of Bacteriostatic Water.
• The Concentration: This creates 200mg per 1ml.
• Syringe Measurement (U-100 Insulin Syringe):
o 25 units (0.25ml) = 50mg
o 50 units (0.50ml) = 100mg
o 100 units (1.0ml) = 200mg

Common Research Dosages:
• Standard Wellness Dose: 100mg – 200mg, 2 to 3 times per week.
• Intensive Detox/Skin Brightening: 200mg, 3 to 5 times per week.
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2. The Cycle (Duration & Timing)
Glutathione is generally used in cycles to support the liver and reduce oxidative stress.

Goal Duration Frequency
General Antioxidant Support 8–12 Weeks 2x per week
Liver/Heavy Metal Detox 4–6 Weeks 3x per week
Skin Clarity/Radiance 12 Weeks 3–5x per week

Timing: Glutathione can be taken anytime, but many researchers prefer evening administration, as the body’s natural detoxification processes are most active during sleep.
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3. Administration: The "Volume" Challenge

Like Lipo-C, Glutathione requires a larger volume of liquid (usually 0.5ml to 1.0ml).

• Subcutaneous (SubQ): This is fine for 50mg–100mg, but 200mg (1ml) can be "heavy" and cause a temporary lump in the stomach fat.

• Intramuscular (IM): For doses of 200mg (1ml), an IM injection in the glute or shoulder is often more comfortable and leads to faster absorption.
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4. Storage & Stability (Crucial)
• The "Rotten Egg" Smell: Glutathione is a sulfur-based compound. It is normal for the powder or the mixed solution to have a slight sulfur/egg smell.

• Refrigeration: Once mixed, it must stay in the fridge. It is highly prone to oxidation.
• Color Check: The solution should be clear. If it turns yellow or cloudy, it has oxidized and lost its potency.
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5. Potential Side Effects
• Zinc Depletion: High-dose Glutathione can deplete zinc levels over time. Supplementing with 15mg–25mg of Zinc is recommended for long cycles.
• Sulfur Sensitivity: If you have a known sulfur allergy, you should avoid Glutathione.
• Detox "Flu": If you have a high toxic load, you may feel temporary fatigue or a mild headache (Herxheimer reaction) as the liver begins processing toxins.
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The "Master Detox" Stack

Researchers often pair Glutathione with NAD+:
1. NAD+: Provides the energy (ATP) for cells to function.
2. Glutathione: Provides the "trash pickup" to remove the oxidative waste generated by high energy production.