Epithalon

Epithalon (also known as Epitalon or by its amino acid sequence AEDG) is a synthetic, four-amino-acid peptide that has been extensively studied for its potential anti-aging and longevity-enhancing properties. It is based on epithalamin, a natural peptide extract from the pineal gland.

Key Mechanisms and Effects
Epithalon is primarily known for its proposed ability to influence key cellular processes related to aging:
--Telomere Maintenance: The most notable effect of Epithalon is its potential to activate telomerase, an enzyme that helps maintain and even lengthen telomeres, the protective caps at the ends of chromosomes that naturally shorten with age. This action may help extend the lifespan of cells.
--Antioxidant Effects: It acts as a potent antioxidant, helping to neutralize free radicals and reduce oxidative stress and DNA damage, which are major contributors to age-related diseases.
--Hormonal Regulation: Epithalon appears to help regulate the endocrine system, particularly by improving the production of melatonin, the hormone essential for regulating sleep-wake cycles and circadian rhythms.
--Immune Function and Anti-tumor Effects: Studies have shown that Epithalon may support immune function and reduce the incidence of spontaneous tumors in animal models, suggesting potential anti-cancer properties.
--Cellular Regeneration: It has been linked to improved tissue regeneration in various areas, including skin, bone, and stomach linings.

Status and Usage
Research on Epithalon largely originates from the St. Petersburg Institute of Bioregulation and Gerontology in Russia, where it has been studied for decades.

Availability: In the United States and European Union, Epithalon is considered a research chemical and is not approved by the FDA for therapeutic or anti-aging use in humans. It is sometimes offered in concierge medical or wellness clinics under physician supervision as part of personalized longevity programs.

Administration: It is typically administered via subcutaneous injection, though oral forms with lower bioavailability exist.

Safety: While studies report a generally mild safety profile with few side effects, the Alzheimer's Drug Discovery Foundation notes that much of the research requires independent confirmation by other labs to fully validate its clinical benefits and long-term safety.