Epithalon

Epitalon (also known as Epithalon or the "Pineal Gland Peptide") is one of the most intriguing longevity research tools. It is a synthetic version of Epithalamin, which is naturally produced in the pineal gland. Its primary role in research is the activation of the enzyme telomerase, which helps repair and lengthen telomeres (the protective caps on the ends of DNA strands).

Because telomere lengthening is a slow, structural process, Epitalon is used in specific, infrequent "bursts" rather than as a daily year-round supplement.
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1. Reconstitution & Dosage

Epitalon typically comes in 10mg, 20mg, or 50mg vials.
• Reconstitution: Add 2ml of Bacteriostatic Water to a 10mg vial.
• The Concentration: This creates 5mg (5,000mcg) per 1ml.
• Syringe Measurement (U-100 Insulin Syringe):
o 10 units (0.10ml) = 500mcg
o 20 units (0.20ml) = 1mg
o 100 units (1.0ml) = 5mg

Common Research Dosages:

There are two main schools of thought for Epitalon dosing based on Russian clinical studies:
• The "Khavinson" Protocol (High Dose): 5mg to 10mg daily for 10–20 days. (Note: This requires large vials and significant volume).
• The "Modern/Biohacker" Protocol (Low Dose): 500mcg to 1mg daily for 20–30 days.
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2. The Cycle (The "Twice-a-Year" Rule)
Epitalon is designed to "reset" the biological clock. Constant use is not recommended as the body needs time to integrate the cellular changes.

Phase Duration Frequency
Active Cycle 10 to 20 Days Once Daily
Rest Period 6 Months OFF

Repeat: Most researchers run this cycle only twice per year.

Timing: Nightly. Because Epitalon influences the pineal gland (which regulates melatonin), injecting it before bed can help reset circadian rhythms and improve sleep quality.
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3. Administration
• Subcutaneous (SubQ): Inject into the abdominal fat. Epitalon is generally painless and has very low injection-site irritation.
• Intranasal: Some research uses nasal sprays for a more direct path to the brain/pineal gland, though

SubQ remains the gold standard for measurable systemic levels.
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4. Storage & Stability
• Refrigeration: Must be kept in the fridge after mixing.
• Stability: Epitalon is a very stable tetrapeptide. It can stay potent for up to 60–90 days in the refrigerator, but since cycles are short, you will likely finish the vial quickly.
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5. Potential Side Effects
Epitalon is remarkably well-tolerated with very few reported side effects.
• Vivid Dreams: Similar to Ipamorelin, the pineal gland activation can lead to intense or very clear dreams.
• Improved Sleep: Many report deeper sleep and waking up feeling more refreshed.
• No Known Toxicity: Clinical trials have shown no significant adverse effects even at higher doses.
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The "Anti-Aging/Bioclock" Stack
Researchers often stack Epitalon with Thymalin:
1. Epitalon: Targets the Pineal gland and DNA (Telomeres).
2. Thymalin: Targets the Thymus gland to "reboot" the immune system.
This duo is known in Russian longevity circles as the "Biochemical Reset."
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Quick Checklist for a 10mg Vial:
• To hit a 1mg dose: Pull to the 20 unit mark (assuming 2ml of water). One vial will last you 10 days.