ARA-290

ARA 290 is a synthetic peptide, derived from erythropoietin (EPO), designed to provide EPO's protective, anti-inflammatory effects without stimulating red blood cell production (erythropoiesis), working by activating the innate repair receptor (IRR) to help heal tissues, reduce neuropathic pain, and improve metabolic issues in conditions like diabetes and sarcoidosis.

Key Characteristics & Functions:

--EPO Derivative: It's a small peptide (11 amino acids) taken from EPO's structure but engineered to only hit the protective pathways, not the red blood cell-boosting ones.
Targets Innate Repair Receptor (IRR): It selectively binds to the IRR, a receptor complex that activates tissue repair and reduces inflammation.

--Anti-inflammatory & Protective: It reduces inflammation, protects organs from injury (like kidney or heart), and helps repair nerve damage.

--Non-hematopoietic: It doesn't cause the rise in red blood cells associated with EPO, avoiding cardiovascular side effects.

Potential Applications & Benefits:

--Neuropathic Pain: Relieves pain in conditions like sarcoidosis-related small fiber neuropathy and diabetic neuropathy.

--Metabolic Control: Improves blood sugar (HbA1c) and lipid profiles in type 2 diabetes.

--Tissue Repair: Shows promise in protecting organs from ischemic injury (like after transplants) and improving recovery.

--Inflammation: Reduces systemic inflammation in various disease models.

In essence, ARA 290 is a targeted therapeutic peptide that offers EPO's healing benefits while bypassing its blood-producing effects, making it useful for nerve damage, metabolic diseases, and inflammation.