

AICAR
What is AICAR?

AICAR (5-aminoimidazole-4-carboxamide ribonucleoside) is a naturally occurring compound and a lab-synthesized drug that mimics exercise by activating AMP-activated protein kinase (AMPK), a key cellular energy sensor, making cells use fat for fuel and create more mitochondria, and is researched for treating metabolic disorders like diabetes and improving athletic performance. It's an adenosine analog that tells the body to conserve energy, increasing glucose uptake and fat burning, essentially mimicking the metabolic effects of working out, and is studied for potential heart, cancer, and anti-inflammatory benefits.
What it does:
--Activates AMPK: AICAR stimulates AMPK, a protein that kicks in when energy is low, like during exercise.
Boosts Energy Production: Activated AMPK increases mitochondria (cell powerhouses) and encourages cells to use fat for energy instead of glucose.
--Mimics Exercise: Its effects on muscle (increased glucose uptake, fat burning) are similar to what happens during physical activity.
Research and potential uses:
--Metabolic Disorders: Studied for treating diabetes, insulin resistance, and metabolic syndrome.
--Cardiovascular Health: May have heart-protective effects.
--Cancer Research: Investigated for potential anti-cancer properties.
--Anti-Inflammatory: Shows promise in reducing inflammation.